Endocrine Abstracts

Rationale and objectives: Validation of new therapeutic regimens in the treatment of hypertension, particularly in poorly controlled patients at high risk for cardiovascular disease, is urgently needed. We evaluated the efficacy and safety of two doses of the candesartan cilexetil/hydrochlorothiazide combination (Blopress Plus®) in hypertensive patients in Jordan.Methods: An observational, multicenter, prospective, open-label study of Jor...

Background: Prostate cancer is the second leading cause of cancer-related deaths in men worldwide. A marker of poor survival in prostate cancer patients is the loss of the tumor suppressor gene PTEN (phosphoinositide-3-phosphatase). Deletion of PTEN occurs in approximately 40% of prostate cancer patients, and is associated with early biochemical recurrence, metastatic potential, and androgen-independence. Androgen-deprivation-therapy (ADT) remains the princip...